Explore the revolutionary field of supramolecular chemistry and self-assembly, where molecules spontaneously organize into complex structures with applications spanning medicine to materials science. This episode delves into the principles, control mechanisms, and future directions of this groundbreaking area.
Key concepts include: - Spontaneous organization of molecules via non-covalent interactions - Bottom-up construction of complex structures - Manipulation of molecular design to influence self-assembly - Applications in targeted drug delivery and advanced materials
Research insights are discussed, citing the work of Thomas Roussel and Lourdes F. Vega (2012) on predicting molecular self-assembly using the SANO code, and Ina Heckelmann et al. (2022) on preserving electronic purity in organic semiconductors through supramolecular self-assembly. These studies highlight the importance of computational modeling and precise control over molecular interactions.
Practical applications include the development of targeted drug delivery systems that release medication only at the site of a tumor, and the creation of new electronic devices, sensors, and catalysts with tailored properties, as well as the integration of nanotechnology and quasicrystals to create functional materials.
Future directions involve the development of more sophisticated computational models, the creation of new functional materials with tailored properties, and breakthroughs in using self-assembly for targeted drug delivery and regenerative medicine. Further study is required in systems with open and closed self-assembly. The work of Andrew B. Cairns, Matthew J. Cliffe, and colleagues shows the encoding of complexity within these systems is crucial.
References
- Martin Castelnovo, Timothée Verdier, Lionel Foret (2014). Comparing open and closed molecular self-assembly. Available: http://arxiv.org/abs/1402.3899v1 DOI: 10.xxxx/xxxx
- Andrew B. Cairns, Matthew J. Cliffe, Joseph A. M. Paddisonet al. (2016). Encoding Complexity within Supramolecular Analogues of Frustrated Magnets. Available: http://arxiv.org/abs/1601.01664v1 DOI: 10.xxxx/xxxx
- Nitin S. Tiwari, Koen Merkus, Paul van der Schoot (2016). Dynamic Landau Theory for Supramolecular Self-Assembly. Available: http://arxiv.org/abs/1605.06943v1 DOI: 10.xxxx/xxxx
- Thomas Roussel, Lourdes F. Vega (2012). The Self-Assembly of Nano-Objects Code: Applications to supramolecular organic monolayers adsorbed on metal surfaces. Available: http://arxiv.org/abs/1211.5434v1 DOI: 10.xxxx/xxxx
- Ron Lifshitz (2008). Nanotechnology and Quasicrystals: From self assembly to photonic applications. Available: http://arxiv.org/abs/0810.5161v1 DOI: 10.xxxx/xxxx
- Ina Heckelmann, Zifei Lu, Joseph C. A. Prenticeet al. (2022). Supramolecular self-assembly as a tool to preserve electronic purity of perylene diimide chromophores. Available: http://arxiv.org/abs/2210.16420v1 DOI: 10.xxxx/xxxx
- Hadi H. Arefi, Takeshi Yamamoto (2017). Self-assembly of a model supramolecular polymer studied by replica exchange with solute tempering. Available: http://arxiv.org/abs/1711.00840v1 DOI: 10.xxxx/xxxx
- Emily R. Russell, Govind Menon (2015). Energ...